Endocrine Abstracts

Objective: To examine different methods of analysing bone health and body composition in children and examine the relationships between these methods.Method: In a LREC approved cross-sectional study, DXA was used to assess bone mineral content (BMC) (at total body (TB), lumbar spine (LS), femur (F) and femoral neck (FN)), cross-sectional moment of inertia (CSMI) at the proximal femur and body composition (defined as Lean mass (LM) and Fat mass (FM)) in 6...

Background: Children with pre-symptomatic type 1 diabetes (T1D) can be identified through testing for circulating islet autoantibodies (AAb). Identifying children at risk reduces diabetic ketoacidosis at onset and allows participation in trials aiming to delay disease onset. Teplizumab is the first immunomodulatory agent licensed in the US to delay the onset of T1D by 3 years in individuals at risk; a licensing decision is awaited in the UK. The EarLy Surveill...